Ethyl 3-((S)-((S)-1,1dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate → HCID 89462355, compound

Participants

Reaction Steps

Ethyl 3-((S)—((S)-1,1dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate, 25-c, (25 g, 76% purity, 48.7 mmol) was dissolved in HCl/dioxane (150 ml, 4 mol/L) and the mixture was stirred at room temperature for 2 h. The mixture was then concentrated under vacuum and the residue was dissolved in H2O (90 ml) and HCl (10 ml). The aqueous phase was extracted with EA (80 ml×5). The pH of the aqueous phase was adjusted to about pH=12 and extracted with EA (100 ml*3). The organic layer was dried over Na2SO4. The solvent was removed to provide crude product, 25-d, (10.55 g) and the crude product was used for the next step directly.

Provenance & Evidence