HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1525294Generated: November 4, 2026
Cyclohexanecarboxaldehyde → HCID 16655337, compound
https://huagongshe.com/reaction/1525294
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 16655337 | HCID 16655337 | 31.1% |
Reaction Steps
Cyclohexanecarbaldehyde, 26-a, (13.6 g, 0.121 mol) in dichloromethane (250 mL) were added (S)-2-methylpropane-2-sulfinamide (17.6 g, 0.145 mol), PPTS (3.03 g, 0.0121 mmol) and anhydrous CuSO4 (58 g, 0.363 mol) and the resulting mixture was stirred at 37° C. overnight. The mixture was then filtrated and the filtrate was concentrated under vacuum. The residue was purified by column chromatography (petroleum ether/ethyl acetate=100/1) to provide the product, 27-a, (14 g, 31.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09079930B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-ad791f6ab34546649016b778a141e35b |
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| Source note | uspto-grants-2015_07 |
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