HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 117702214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 89462303 | HCID 89462303 | — |
| Reactant | HCID 131733144 | HCID 131733144 | — |
| Reactant | HCID 178476778 | HCID 178476778 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 117702214 | HCID 117702214 | 90% |
Reaction Steps
To (S)—N—((S)-(4-bromophenyl)(cyclohexyl)methyl)-2-methylpropane-2-sulfinamide, 27-b. (4.887 g, 13.13 mmol), ethyl methylphosphite (2.84 g, 26.26 mmol) and Et3N (3.98 g, 39.4 mmol) in THF (100 ml) was added PdCl2(dppf) (1.5 g). The mixture was allowed to stir overnight at reflux. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was taken into dichloromethane and washed with brine. The organic layer was concentrated under vacuum and the residue was purified over silica gel (diluting with ethyl acetate) to provide the product, 27-c, (5.0 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079930B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-f77f256bd2054e8c89f01eb4716a48c1 |
| Source note | uspto-grants-2015_07 |