1,4-Dioxane hydrochloride → HCID 89462086, compound

HRID 1525297Notes

Reaction equation

HRID 1525297 reaction equation
[CH:1]1([C@H:7]([NH:20][S@](C(C)(C)C)=O)[C:8]2[CH:13]=[CH:12][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:27].O1CCOCC1>>[ClH:27].[NH2:20][C@@H:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:8]1[CH:9]=[CH:10][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 117702214HCID 117702214, compound2×

Product 1

HCID 89462086HCID 89462086, compound

Procedure

Ethyl 4-((S)-cyclohexyl((S)-1,1-dimethylethylsulfinamido)methyl)phenyl(methyl)phosphinate, 27-c, (5.0 g, 12.5 mmol) was dissolved in HCl/dioxane (100 mL) and the mixture was stirred at room temperature for 2 h. The reaction mixture was then concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 27-d, (4.2 g, 90%).

Workup

  1. concentrationThe reaction mixture was then concentrated under vacuum
  2. washthe residue was washed with ethyl acetate
  3. customto provide the product, 27-d, (4.2 g, 90%)

Sources & evidence

ORD record
ord-cb23009a32d7426288e4072a979f99b3
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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