反应详情

温度

78 °C

Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate, 28-f, (1 g, 3.9 mmol) was dissolved in EtOH (7 mL) and KOH (0.67 g, 11.9 mmol) in H2O (3 mL) was added. The mixture was stirred at 78° C. for 1.5 h. Then the solvent was evaporated, and the residue was added about 10 mL of H2O and filtered. The solid was dried and washed by EtOH (5 mL) to give the title product, 28-g, (0.7 g).

1. customThen the solvent was evaporated
2. additionthe residue was added about 10 mL of H2O
3. filtrationfiltered
4. customThe solid was dried
5. washwashed by EtOH (5 mL)