Potassium Hydroxide → HCID 178524763, compound

HRID 1525302Notes

Reaction equation

HRID 1525302 reaction equation
[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([O:16]CC)=[O:15])=[CH:9][N:8]=2)[CH:6]=1.[OH-].[K+]>CCO.O>[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([OH:16])=[O:15])=[CH:9][N:8]=2)[CH:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 178469812Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate2×

Product 1

HCID 178524763HCID 178524763, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
78 °C

Procedure

Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate, 28-f, (1 g, 3.9 mmol) was dissolved in EtOH (7 mL) and KOH (0.67 g, 11.9 mmol) in H2O (3 mL) was added. The mixture was stirred at 78° C. for 1.5 h. Then the solvent was evaporated, and the residue was added about 10 mL of H2O and filtered. The solid was dried and washed by EtOH (5 mL) to give the title product, 28-g, (0.7 g).

Workup

  1. customThen the solvent was evaporated
  2. additionthe residue was added about 10 mL of H2O
  3. filtrationfiltered
  4. customThe solid was dried
  5. washwashed by EtOH (5 mL)

Sources & evidence

ORD record
ord-abf3df972ba24d85b74d26bf5cf05d34
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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