Anisole → (4-Methoxyphenyl)(4-methylphenyl)methanone

Participants

Reaction Steps

To a solution of 4-methylbenzoyl chloride, 32-a, (10 g, 65 mmol) and anisole (8.8 g, 81 mmol) in DCM anhydrous was added aluminum(III) chloride (10.8 g, 81 mmol), the reaction mixture was then stirred for 10 h at ambient temperature. The resulting mixture was concentrated under reduce pressure, 100 ml of water was added, filtered, the residue was dried in vacuo. The product was obtained as a white solid, 32-b, (14 g, 95% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.25 (s, 3H), 3.71 (s, 3H), 6.85-6.89 (m, 2H), 7.11-7.19 (m, 6H). LC-MS 227 [MH]+.

Provenance & Evidence