Hydrochloric Acid → HCID 89462193, compound

Participants

Reaction Steps

To a solution of N-(2-(6-chloropyridin-3-yl)propan-2-yl)acetamide, 33-c, (25 g, 0.12 mol) in MeCN (400 ml) was added NaI (353 g, 2.35 mol) and concentrated HCl (48 ml, 0.59 mol). The reaction mixture was then refluxed for 60 hours. Product conversion was monitored by LC-MS. The reaction mixture was filtered and the cake was washed with MeCN. The filtrate was concentrated under vacuo and the residue was diluted with ethyl acetate, washed with saturated aqueous Na2S203 and brine, dried and concentrated to give the product, 33-d, as a white solid (22 g, 61%).

Provenance & Evidence