Sulfuric Acid → 2-Isopropoxybenzoic acid

HRID 1525351노트

반응식

HRID 1525351 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:8](O)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:12](O)([CH3:14])[CH3:13].S(=O)(=O)(O)O>CCCCCC>[CH:12]([O:1][C:2]1[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=1)[C:4]([OH:6])=[O:5])([CH3:14])[CH3:13]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 34692,5-Dihydroxybenzoic acidHCID 3776Isopropanol

생성물 1

HCID 123576742-Isopropoxybenzoic acid

시약·촉매·용매 1

HCID 8058Hexane용매

반응 조건

온도
75 °C

실험 절차

201 g mixture of 2,5-dihydroxy benzoic acid and isopropanol was added to 1201 g of 80% sulfuric acid and stirred for 8 hours at 75° C. The solution was allowed to cool, and was added with 2 liters of ice water and 140 ml of hexane and was stirred in an ice bath. Resultant crystal deposit was filtrated, and the residue was washed with hexane. Then, it was dispersed in a mixture liquid consisting of methanol and water in a ratio of 6:4, and filtration was conducted. The substance was dried for 48 hours at 60° C., and 65.4 g of isopropyl-salicylic acid intermediate was obtained.

후처리

  1. temperatureto cool
  2. stirringwas stirred in an ice bath
  3. filtrationResultant crystal deposit was filtrated
  4. washthe residue was washed with hexane
  5. additionThen, it was dispersed in a mixture liquid
  6. filtrationconsisting of methanol and water in a ratio of 6:4, and filtration
  7. customThe substance was dried for 48 hours at 60° C.

출처 및 근거

ORD 기록
ord-80920ffad61347658efd0e04b8890537
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079989B2

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