HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-phenyl-1H-pyrazol-5-amine → 4-chloro-5-(4-fluorophenyl)-1-methyl-3-phenyl-1H-pyrazolo[3,4-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-phenyl-1H-pyrazol-5-amine | HCID 517779 | — |
| Reactant | 1-Ethynyl-4-fluorobenzene | HCID 522627 | — |
| Reactant | 4-chloro-3-(2-chlorophenyl)-1-methyl-5-phenyl-1H-pyrazolo[3,4-c]pyridazine | HCID 66576482 | — |
| Product | 4-chloro-5-(4-fluorophenyl)-1-methyl-3-phenyl-1H-pyrazolo[3,4-c]pyridazine | HCID 66576721 | — |
Reaction Steps
Compound 4 was synthesised following similar procedures outlined in Example 1 (Compound 37), starting from Step 2 using 1-methyl-3-phenyl-1H-pyrazol-5-amine instead of 3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-amine and 4-fluorophenylacetylene instead of phenyl acetylene in Step 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079909B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-6b26d82cb9154acb8823d56924f1a392 |
| Source note | uspto-grants-2015_07 |