HRID1525396

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78013

Piperazine, 1-isopropyl-

C7H16N2

结构：O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21

HCID66575782

未命名化合物

结构：CN1CCN(C(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)CC1

HCID66576642

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCN(C(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)CC1

HCID66575779

未命名化合物

PROCEDURE

实验过程

Compound 38 was synthesised from 2-(4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)acetic acid following a similar procedure outlined in Example 17 (Compound 1), using N-isopropylpiperazine instead of N-methylpiperazine in the final step.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ddd543133f964b179d6d26d2a67824cf
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09079909B2
来源说明: uspto-grants-2015_07

反应 SMILES

[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:23][C:24](O)=[O:25])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12.ClC1C(C2C=CC=CC=2)=NN=C2N(CC(N3CCN(C)CC3)=O)N=C(C3C=CC=CC=3)C=12.[CH:59]([N:62]1[CH2:67][CH2:66][NH:65][CH2:64][CH2:63]1)([CH3:61])[CH3:60]>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:23][C:24]([N:65]3[CH2:66][CH2:67][N:62]([CH:59]([CH3:61])[CH3:60])[CH2:63][CH2:64]3)=[O:25])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12