HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Fluorophenyl)-3-oxopropanenitrile → 2-(4-chloro-3-(3-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-1-morpholinoethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Fluorophenyl)-3-oxopropanenitrile | HCID 2758948 | — |
| Reactant | 2-(4-chloro-3-(4-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-1-morpholinoethanone | HCID 66576174 | — |
| Product | 2-(4-chloro-3-(3-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-1-morpholinoethanone | HCID 66576175 | — |
Reaction Steps
Example 69 (Compound 76) was synthesised following a similar procedure outlined in Example 68 (Compound 75), using 3-fluorobenzoylacetonitrile instead of 4-fluorobenzoylacetonitrile in step 1. Compound 76 was obtained as a yellow solid (4.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079909B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-32fe9b3aeef94a5397d080bd63257f94 |
| Source note | uspto-grants-2015_07 |