HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Glutamine, N2-[(phenylmethoxy)carbonyl]- → HCID 66825788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Glutamine, N2-[(phenylmethoxy)carbonyl]- | HCID 75855 | — |
| Reactant | 3-Aminopiperidine-2,6-dione hydrochloride | HCID 134548 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66825788 | HCID 66825788 | — |
Reaction Steps
α-aminoglutarimide hydrochloride is commercially unavailable internally. It is synthesized from N-benzyloxycarbony-L-glutamine, which reacts with N,N′-carbonyldiimidazole in THF refluxing to yield N-benzyloxycarbony-aminoglutarimide. After that amino protection group is removed and α-aminoglutarimide hydrochloride is yielded by hydrogenation under certain pressure catalyzed with Pd/C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085530B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-b44916c04cd94dce8cab6c8cfa724e77 |
| Source note | uspto-grants-2015_07 |