HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → Lenalidomide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione | HCID 11471781 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Lenalidomide | HCID 216326 | 89.3% |
Reaction Steps
A mixture of 3-(4-nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (7 g), 5% Pd/C (1.4 g) and ammonium formate (2.1 g) in methanol (35 ml) was stirred completely at room temperature for 2 hours. Pd/C was filtered and the filtrate concentrated to dry under reduced pressure. Recrystallization from heated isopropanol and washing with water gave 5.6 g of yellow crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085530B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-a80ce1909bfe48e48dde3d6d994e0694 |
| Source note | uspto-grants-2015_07 |