Ammonia → HCID 86668436, compound

Participants

Reaction Steps

Crude 1-(2,3-Dihydroxy-4-hydroxymethyl-cyclopentyl)-3-methoxycarbonyl-pyridinium-methansulfonate 118.3 g, 173.7 mmol) was dissolved in 100.0 ml methanol. After the addition of methanolic ammonia (7M, 350.0 ml, 2.45 mol) the reaction mixture was stirred for 2.5 h. After removing the solvent under reduced pressure a red-brown oil was obtained that was further dried for 3 h (40° C., 10 mbar). This crude product is pre-purified with activated charcoal and used directly for the synthesis of cNAD (WO 2007/012494).

Provenance & Evidence