反应详情

To a solution of ethyl 4-(bromomethyl)-2,5-difluorobenzoate (Preparation 13, 200 mg, 0.72 mmol) in N,N-dimethylformamide (4 mL) at room temperature under nitrogen was added 5-chloro-6-isopropoxypyridin-3-ol (Preparation 6, 161 mg, 0.86 mmol) and potassium carbonate (198 mg, 1.43 mmol). The reaction was stirred at room temperature for 2 days, then partitioned between water and ethyl acetate (1:1 10 mL). The organic phase was washed with brine (10 mL), dried over magnesium sulfate, filtered and the solvent removed in vacuo to afford the title compound as a light yellow solid (400 mg, >100%). No further purification undertaken.

1. custompartitioned between water and ethyl acetate (1:1 10 mL)
2. washThe organic phase was washed with brine (10 mL)
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customthe solvent removed in vacuo