Benzenemethanamine, 3,4-dichloro- → Methyl 3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylate
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].Br[C:12]1[CH:21]=[N:20][CH:19]=[CH:18][C:13]=1[C:14]([O:16][CH3:17])=[O:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:6][C:18]1[CH:19]=[N:20][CH:21]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15]Komponenten
3
Versuchsvorschrift
The title compound was prepared in 73% yield from 3,4-dichlorobenzylamine and methyl 3-bromoisonicotinate according to the procedure for Preparation 4A. 1H NMR (400 MHz, CDCl3): δ 8.10 (s, 1H), 7.95 (d, 1H, J=5.1 Hz), 7.87 (br s, 1H), 7.65 (d, 1H, J=5.1 Hz), 7.42 (d, 1H, J=8.7 Hz), 7.39 (s, 1H), 7.18 (dd, 1H, J=8.2 Hz), 4.48 (d, 2H, J=6.0 Hz), 3.91 (s, 3H). [M+H] calc'd for C14H12Cl2N2O2, 311, 313; found 311, 313.
Quellen und Nachweise
- ORD-Eintrag
- ord-466df4aa12ac4061af0e3929b93ac7c2
- Quelldatensatz
- uspto-grants-2015_07
- Patentnummer
- US09085534B2
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