反应详情

温度

40 °C

To a solution of 6-methoxy-1-tetralone (200 mg, 1.1 mmol) in ACN (20 mL) was added Selectfluor (603 mg, 1.7 mmol) at rt, and the reaction was stirred at 40° C. overnight. The reaction was filtered and concentrated. The residue was dissolved in EtOAc (40 mL), filtered, and concentrated. Purification by silica gel chromatography (PE/EtOAc/DCM=20:1:2) gave 90 mg (41%) of the title compound as a yellow solid. [M+H] Calc'd for C11H11FO2, 195; Found, 195.

1. filtrationThe reaction was filtered
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in EtOAc (40 mL)
4. filtrationfiltered
5. concentrationconcentrated
6. customPurification by silica gel chromatography (PE/EtOAc/DCM=20:1:2)