Hydrochloride methanol → 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

HRID 1525811Notes

Reaction equation

HRID 1525811 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:2].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:35](=[O:36])[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28]2=[O:37])[C:21]1=[O:38].[ClH:39].CO>C(Cl)Cl>[ClH:39].[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:16].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:28](=[O:37])[C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:35]2=[O:36])[C:21]1=[O:38]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 710827862-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate

Product 1

HCID 866187522-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (76 mg) obtained from example 6 was dissolved in DCM (10 mL) and 15% HCl/methanol solution (5 mL) were added dropwise. The solvent was eliminated by rotary evaporation in vacuo and then white solid (82 mg) was obtained.

Workup

  1. customThe solvent was eliminated by rotary evaporation in vacuo

Sources & evidence

ORD record
ord-45671870be1d4665bec8b305410ff9c0
Source dataset
uspto-grants-2015_07
Patent number
US09085563B2

Reaction notes

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