Lithium Hydroxide → 3-(4-Cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-3-(4-(quinolin-7-yl)phenyl)propanoic acid

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Reaction Steps

A solution of methyl 3-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-3-(4-(quinolin-7-yl)phenyl)propanoate (0.238 mmol) in ethanol (1 mL) was treated with LiOH (0.476 mmol) and stirred at room temperature for four days. The reaction mixture was concentrated in vacuo and the residue purified by reverse phase HPLC (15-50% acetonitrile/water with 0.1% NH4OH) to afford the title compound as a white solid (72%). MS(ES)+ m/e 486.3 [M+H]+.

Provenance & Evidence