反应详情

温度

100 °C

Into a 100 mL round bottom flask was placed tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (2 g, 9.38 mmol). To this was added 2M ethanamine in methanol (23.44 ml, 46.9 mmol). A condenser was attached to the flask and the solution was stirred at reflux (100° C.) overnight. The solution was cooled and concentrated in vacuo to afford the title compound (2.4 g) which was carried forward without further purification. MS(ES)+ m/e 259.1 [M+H]+.

1. customInto a 100 mL round bottom flask was placed
2. customA condenser was attached to the flask
3. temperatureThe solution was cooled
4. concentrationconcentrated in vacuo