HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinyl-4-(trifluoromethyl)pyridine → 4-Pyridin-3-yl-2-[4-(trifluoromethyl)pyridin-2-yl]-1,2-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinyl-4-(trifluoromethyl)pyridine | HCID 15150714 | — |
| Reactant | 3-Hydroxy-2-pyridin-3-yl-acrylic acid ethyl ester | HCID 68708088 | — |
| Product | 4-Pyridin-3-yl-2-[4-(trifluoromethyl)pyridin-2-yl]-1,2-dihydro-3H-pyrazol-3-one | HCID 59186930 | — |
Reaction Steps
The compound is prepared analogously to Example 2 from 18 mg (0.09 mmol) of the compound from Example 2A and 18 mg (0.10 mmol) 2-hydrazino-4-(trifluoromethyl)pyridine [R. A. Evans, C. Wentrup, J. Chem. Soc. Chem. Commun. 15, 1062-1064 (1992)]. 11.7 mg (41% of th.) of the title compound are obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085572B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-d6f356c9113646bab479d9e8f4654885 |
| Source note | uspto-grants-2015_07 |