HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyric Acid → HCID 68706771, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyric Acid | HCID 264 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 68704213 | HCID 68704213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68706771 | HCID 68706771 | — |
Reaction Steps
80.0 mg (235 μmol) of the compound from Example 35 and 22.8 mg (259 μmol) butyric acid are dissolved in 5 ml DMF, 119 mg (1.18 mmol) triethylamine and 90.2 mg (470 μmol) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride are added, while cooling with ice, and the mixture is stirred overnight at RT. The reaction mixture is then purified directly by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% conc. hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085572B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-6644797afb764e13808550e6c5645c7a |
| Source note | uspto-grants-2015_07 |