Methanol → HCID 59186993, compound

HRID 1526094Notes

Reaction equation

HRID 1526094 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=2)[C:10]([OH:12])=[O:11])[NH:5][CH:4]=[C:3]1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1.S(=O)(=O)(O)O.[CH3:27]O>>[CH3:27][O:11][C:10](=[O:12])[C:9]1[CH:13]=[CH:14][N:15]=[C:7]([N:6]2[C:2](=[O:1])[C:3]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)=[CH:4][NH:5]2)[CH:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 59186979HCID 59186979, compound

Product 1

HCID 59186993HCID 59186993, compound

Procedure

150 mg (531 μmol) of the compound from Example 41 are dissolved in 20 ml methanol, 1 ml concentrated sulfuric acid are added and the mixture is heated under reflux overnight. After cooling, the precipitate formed is filtered off with suction, washed with methanol and dried.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling
  4. customthe precipitate formed
  5. filtrationis filtered off with suction
  6. washwashed with methanol
  7. customdried

Sources & evidence

ORD record
ord-e1b3ba3920724ae99d3b3de4c4582d20
Source dataset
uspto-grants-2015_07
Patent number
US09085572B2

Reaction notes

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