Hydrochloric Acid → HCID 68706552, compound

Participants

Reaction Steps

197 mg (1.77 mmol) calcium chloride and 319 mg (8.44 mmol) sodium borohydride are initially introduced into 26 ml ethanol, 50 mg (169 μmol) of the compound from Example 42 are added in portions at 0° C. and the mixture is stirred overnight at RT. The reaction mixture is adjusted to a slightly acid pH by addition of 1 M hydrochloric acid and concentrated and the residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% conc. hydrochloric acid).

Provenance & Evidence