HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 68706447, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 68704213 | HCID 68704213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68706447 | HCID 68706447 | — |
Reaction Steps
80.0 mg (235 μmol) of the compound from Example 35 are dissolved in 5 ml DMF, 71.4 mg (705 μmol) triethylamine and 20.3 mg (259 μmol) acetyl chloride are added, while cooling with ice, and the mixture is stirred overnight at RT. The reaction mixture is purified directly by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% conc. hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085572B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-beb0b2fb86fa42708e8215e3f79d86f0 |
| Source note | uspto-grants-2015_07 |