HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 68706385, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 68704213 | HCID 68704213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68706385 | HCID 68706385 | — |
Reaction Steps
60.0 mg (176 μmol) of the compound from Example 35 are dissolved in 4 ml DMF, 53.5 mg (529 μmol) triethylamine and 27.3 mg (194 μmol) benzoyl chloride are added, while cooling with ice, and the mixture is stirred overnight at RT. The reaction mixture is purified directly by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% conc. hydrochloric acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085572B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-ada8cd6c94a64de782455e544a6114c1 |
| Source note | uspto-grants-2015_07 |