反应详情

5.43 g (62.4 mmol) of manganese oxide is added to 4.5 g (12.49 mmol) of 4-(2-fluorophenyl)-6-(4-methoxyphenyl)-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile in solution in 60 ml of dichloromethane and 15 ml of methanol. The reaction mixture is placed in an ultrasonic bath for 5 minutes and then stirred at room temperature for 20 hours before being filtered on Dicalite. The filtrate is evaporated to yield 4.1 g (92%) of 4-(2-fluorophenyl)-6-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile in the form of a yellow solid.

1. filtrationbefore being filtered on Dicalite
2. customThe filtrate is evaporated