Acetic Acid → HCID 136338238, compound

Participants

Reaction Steps

55 mg (1 mmol) of iron is added to a solution of 87 mg (0.2 mmol) of ethyl 3-amino-6-(4-methoxyphenyl)-4-(2-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate dissolved in 2 ml of acetic acid. The reaction medium is carried at 90° C. for 5 hours, and then the precipitate obtained is filtered on Dicalite and rinsed with a 98:2 dichloroethane/methanol mixture. The filtrate is concentrated to yield 45 mg (56%) of N-(5-(4-methoxyphenyl)-6-oxo-6,7-dihydro-3H-benzo[f]pyrazolo[3,4-c][2,7]naphthyridin-1-yl)acetamide in the form of a yellow solid.

Provenance & Evidence