Acetic Acid → HCID 89709223, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-aminophenoxy)-3-{[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-3-methylphenyl]amino}-6-ethylpyrazine-2-carboxamide (840 mg) and 3 M hydrochloric acid (6 mL) was stirred at 80° C. for 5 hours, and then acetic acid (1.5 mL) was added thereto, followed by stirring at 80° C. overnight. The reaction mixture was left to be cooled, and then water (30 mL) was added thereto, followed by ice-cooling. The pH was adjusted to 9 by the addition of concentrated ammonia. The precipitated solid was collected by filtration and then dried under reduced pressure to obtain 5-(3-aminophenoxy)-6-ethyl-3-{[3-methyl-4-(4-oxopiperidin-1-yl)phenyl]amino}pyrazine-2-carboxamide (0.74 g) as a pale yellow solid.

Provenance & Evidence