HCID 117666904, compound → HCID 117667269, compound

HRID 1526231Notes

Reaction equation

HRID 1526231 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:4][C@H:3]1[CH2:17][OH:18]>[Pd].C(O)C>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[C@H:3]([CH2:17][OH:18])[CH2:4]2)=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 117666904HCID 117666904, compound

Product 1

HCID 117667269HCID 117667269, compoundYield 100.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixture of [(2S)-1-methyl-4-(4-nitrophenyl)piperazin-2-yl]methanol (315 mg) and ethanol (5.081 mL) was added 10% palladium-supported carbon (53% wet product) (267 mg), followed by stirring at room temperature for 4 hours under a hydrogen gas atmosphere (1 atm). The reactant was filtered through celite and then the solvent was evaporated under reduced pressure to obtain [(2S)-4-(4-aminophenyl)-1-methylpiperazin-2-yl]methanol (278 mg) as a solid.

Workup

  1. filtrationThe reactant was filtered through celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cedeade250814ff193eee9674ee4a53c
Source dataset
uspto-grants-2015_07
Patent number
US09085540B2

Reaction notes

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