Methanesulfonic Acid → HCID 117666883, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-[3-(acryloylamino)phenoxy]-6-ethyl-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrazine-2-carboxamide (100 mg) and acetonitrile (3 mL) was heated to 50° C., and a 2 M aqueous methanesulfonic acid solution (100 μl) was added thereto, followed by stirring at 50° C. for 30 minutes. After leaving to be cooled to room temperature, the mixture was stirred at room temperature for 15 hours. The precipitated solid was collected by filtration and dried at 50° C. for 6 hours under reduced pressure to obtain 5-[3-(acryloylamino)phenoxy]-6-ethyl-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrazine-2-carboxamide monomethanesulfonate (104 mg) as a pale yellow solid.

Provenance & Evidence