Sodium hydride → HCID 117770681, compound

Participants

Reaction Steps

To a solution of 4,6-dichloropyrimidine (600 mg) and 1-(2-hydroxyethyl)-2-pyrrolidinone (0.728 mL) in N,N-dimethylformamide (2 mL) was added sodium hydride (60% oil, 209 mg) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was poured into saturated aqueous ammonium chloride solution (10 mL), water (5 mL) was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with, water (10 mL, threetimes) and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained pale-yellow oil was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (634 mg).

Provenance & Evidence