Hydrochloric Acid → HCID 117770541, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-1-(2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde obtained in Step B (6.00 g), hydroxylamine hydrochloride (2.53 g), conc. hydrochloric acid (0.0740 mL) and 2-propanol (60 mL) was heated at 100° C. for 2 hr, and the mixture was cooled to room temperature, and concentrated under reduced pressure. To the residue was added ethyl acetate, and the mixture was washed with water and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (6.02 g).

Provenance & Evidence