Phosphorus oxychloride → HCID 117770476, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-3-((hydroxyimino)methyl)-1-(2-methylphenyl)pyridin-2(1H)-one obtained in Step C (6.36 g) in acetonitrile (60 mL) was added phosphorus oxychloride (2.93 mL) at room temperature. The reaction mixture was heated at 90° C. for 1 hr, cooled to room temperature, and poured into ice water. The resulting solid was collected by filtration to give the title compound (3.15 g).

Provenance & Evidence