Hydroxyamine hydrochloride → HCID 117770397, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-1-(3-methylbutan-2-yl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde obtained in Step C (400 mg), hydroxylamine hydrochloride (244 mg) and sodium acetate (288 mg) in methanol/water (4:1, 6.0 mL) was heated at 75° C. for 1 hr, and cooled to room temperature. The reaction mixture was poured into ice water, and the resulting solid was collected by filtration, washed with water, and dried under reduced pressure to give the title compound (328 mg).

Provenance & Evidence