Phosphorus oxychloride → HCID 117770690, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-3-((hydroxyimino)methyl)-1-(3-methylbutan-2-yl)pyridin-2(1H)-one obtained in Step D (328 mg) in acetonitrile (3.0 mL) was added phosphorus oxychloride (0.126 mL) at room temperature. The reaction mixture was heated at 90° C. for 30 min, and cooled to room temperature. The reaction mixture was poured into ice water, and the mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (305 mg).

Provenance & Evidence