Tetrahydrofuran → HCID 4076513, compound

Participants

Reaction Steps

To a mixture of 2-methylcyclohexanamine (2.00 g), 2,2,6-trimethyl-4H-1,3-didioxin-4-one (3.26 g) and tetrahydrofuran (5.0 mL) was added sodium acetate (1.45 g) at room temperature. The reaction mixture was refluxed overnight, and cooled to room temperature. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.99 g).

Provenance & Evidence