Dimethylformamide dimethyl acetal → HCID 131733163, compound

Participants

Reaction Steps

To a solution of N-(2-methylcyclohexyl)-3-oxobutanamide obtained in Step A (1.99 g) in N,N-dimethylformamide (20 mL) was added dropwise 1,1-dimethoxy-N,N-dimethylmethanamine (2.41 g) over 10 min at room temperature, and the reaction mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/dichloromethane) to give the title compound (1.94 g).

Provenance & Evidence