HCID 137001369, compound → HCID 117770222, compound

HRID 1526335Notes

Reaction equation

HRID 1526335 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13]([CH3:14])=[CH:12][C:11]([OH:15])=[C:10]([CH:16]=[N:17]O)[C:9]1=[O:19]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13]([CH3:14])=[CH:12][C:11]([OH:15])=[C:10]([C:16]#[N:17])[C:9]1=[O:19]

Participants

3

Reactant 1

HCID 137001369HCID 137001369, compound

Product 1

HCID 117770222HCID 117770222, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 1-(2-chlorophenyl)-4-hydroxy-3-((hydroxyimino)methyl)-6-methylpyridin-2(1H)-one obtained in Step C (3.88 g) and acetic acid (46.4 mL) was stirred at 120° C. for 2 hr, cooled to room temperature, and poured into ice water. The resulting solid was collected by filtration, washed with water, and dried under reduced pressure to give the title compound (2.90 g).

Workup

  1. temperaturecooled to room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-eb5229f613044ee6bc5f9a46a5ee02a9
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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