Phthalic Anhydride → HCID 117770562, compound

HRID 1526340Notes

Reaction equation

HRID 1526340 reaction equation
[NH2:1][C:2]1[C:6]2[C:7](=[O:20])[N:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:9]([CH2:11][OH:12])=[CH:10][C:5]=2[NH:4][N:3]=1.[C:21]1(=O)[O:26][C:24](=[O:25])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12>O1CCOCC1>[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:8]1[C:9]([CH2:11][OH:12])=[CH:10][C:5]2[NH:4][N:3]=[C:2]([N:1]3[C:24](=[O:25])[C:23]4[C:22](=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:21]3=[O:26])[C:6]=2[C:7]1=[O:20]

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 117770456HCID 117770456, compound

Product 1

HCID 117770562HCID 117770562, compoundYield 49.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-amino-5-(2-chlorophenyl)-6-(hydroxymethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one obtained in Step H (450 mg), phthalic anhydride (321 mg) and 1,4-dioxane (5.20 mL) was refluxed overnight, and cooled to room temperature. The resulting solid was collected by filtration, and washed with ethyl acetate to give the title compound (320 mg).

Workup

  1. temperaturewas refluxed overnight
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-f27436be98ec41d4b58728e2264c177a
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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