HCID 117770577, compound → HCID 117769950, compound

HRID 1526365Notes

Reaction equation

HRID 1526365 reaction equation
[NH2:1][C:2]1[C:6]2[C:7](=[O:17])[N:8]([CH:12]([CH:14]([CH3:16])[CH3:15])[CH3:13])[CH:9]=[C:10]([Br:11])[C:5]=2[NH:4][N:3]=1>CCCCCC.C(O)C>[NH2:1][C:2]1[C:6]2[C:7](=[O:17])[N:8]([C@H:12]([CH:14]([CH3:16])[CH3:15])[CH3:13])[CH:9]=[C:10]([Br:11])[C:5]=2[NH:4][N:3]=1

Participants

3

Reactant 1

HCID 117770577HCID 117770577, compound

Product 1

HCID 117769950HCID 117769950, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 21879635Ethanol hexaneSolvent

Procedure

Racemic 3-amino-7-bromo-5-(3-methylbutan-2-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one obtained in Step G of Example 13 (7.89 g) was resolved by HPLC (column: CHIRALPAK AD, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/ethanol=600/400(v/v)) to give the title compound (3.751 g) having a shorter retention time.

Sources & evidence

ORD record
ord-047e40339be5401e8ec9405d0fe2f86e
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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