Bromine → HCID 117770421, compound

HRID 1526386Notes

Reaction equation

HRID 1526386 reaction equation
[NH2:1][C:2]1[C:6]2[C:7](=[O:23])[N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([NH:18][C:19](=[O:21])[CH3:20])=[CH:13][C:12]=3[F:22])[CH:9]=[CH:10][C:5]=2[NH:4][N:3]=1.[Br:24]Br>C(O)(=O)C>[BrH:24].[NH2:1][C:2]1[C:6]2[C:7](=[O:23])[N:8]([C:11]3[C:12]([F:22])=[CH:13][C:14]([NH:18][C:19](=[O:21])[CH3:20])=[CH:15][C:16]=3[F:17])[CH:9]=[C:10]([Br:24])[C:5]=2[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 117770079HCID 117770079, compound

Product 1

HCID 117770421HCID 117770421, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a mixture of N-(4-(3-amino-4-oxo-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-3,5-difluorophenyl)acetamide obtained in Step D (0.67 g) and acetic acid (30 mL) was slowly added bromine (0.21 mL) at 80° C., and the reaction mixture was stirred at 80° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was recrystallized from acetic acid to give the title compound (0.65 g).

Workup

  1. customat 80° C.
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was recrystallized from acetic acid

Sources & evidence

ORD record
ord-df0b3131fa604bc686a6c6670e734dc8
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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