Bromine → HCID 117770655, compound

HRID 1526393Notes

Reaction equation

HRID 1526393 reaction equation
[NH2:1][C:2]1[C:6]2[C:7](=[O:18])[N:8]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][C:12]=3[Cl:17])[CH:9]=[CH:10][C:5]=2[NH:4][N:3]=1.[Br:19]Br>C(O)(=O)C>[BrH:19].[NH2:1][C:2]1[C:6]2[C:7](=[O:18])[N:8]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][C:12]=3[Cl:17])[CH:9]=[C:10]([Br:19])[C:5]=2[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 117770847HCID 117770847, compound

Product 1

HCID 117770655HCID 117770655, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture of 3-amino-5-(3-chloropyridin-4-yl)-1H-pyrazolo[4,3-c]pyridin-4(5H)-one obtained in Step D (0.25 g) and acetic acid (30 mL) was slowly added bromine (0.10 mL) at 60° C., and the reaction mixture was stirred at 60° C. for 3 hr. The solvent was evaporated under reduced pressure, and the residue was recrystallized from acetic acid to give the title compound (0.27 g).

Workup

  1. customat 60° C.
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was recrystallized from acetic acid

Sources & evidence

ORD record
ord-d07ac8c145bf47ef8d2ae9e790a464d8
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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