Trifluoroacetic acid → HCID 178486657, compound

Participants

Reaction Steps

A mixture of 4-methoxy-2-((4-methoxybenzyl)oxy)-5-(1-methyl-1H-pyrazol-3-yl)nicotinonitrile obtained in Step C (0.81 g) and trifluoroacetic acid (2.6 g) was stirred at room temperature for 15 min, and the solvent was evaporated under reduced pressure. To the residue was added a mixed solvent (5 mL) of isopropyl ether/ethyl acetate=1/1, and the mixture was stirred for 15 min. The precipitate was collected by filtration to give the title compound (0.57 g).

Provenance & Evidence