Hydrochloric Acid → HCID 117770785, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-1-((2S)-3-methylbutan-2-yl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde obtained in Step C (31.8 g) in 2-propanol (300 mL) were added hydroxylamine hydrochloride (14.6 g) and conc. hydrochloric acid (0.43 mL), and the mixture was stirred at 100° C. for 1 hr. The reaction mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure. The residue was crystallized from (2-propanol/diisopropyl ether), and the resulting solid was collected by filtration, and washed with 2-propanol/diisopropyl ether to give the title compound (23.2 g).

Provenance & Evidence