Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid | HCID 53362086 | — |
| Reactant | HCID 178418600 | HCID 178418600 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 178458456 | HCID 178458456 | — |
Reaction Steps
(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (15 mg) was dissolved in acetone (0.5 mL) and heated to 60° C. Aqueous L-arginine (14 uL, 2.22 M) was added and the reaction mixture was cooled to 35° C. Water (14 uL) was then added and the mixture was stirred for 24 h. The reaction mixture was concentrated to dryness and EtOAc was added to provide a white solid which was collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09085581B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-c8dcb2a74c744c6a9f1c89022db40f1a |
|---|
| Source note | uspto-grants-2015_07 |
|---|
