N-Methyl-D-glucamine → (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid N-methylglucamine salt

Participants

Reaction Conditions

Reaction Steps

(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (15 mg, 0.0311 mmol) was dissolved in acetone (0.5 mL) and warmed to 50° C. Aqueous N-methylglucamine (14 uL, 2.27M) was added and the mixture was allowed to slowly cool to 30° C. over 24 h. The reaction mixture was evaporated to dryness, and EtOAc (0.5 mL) was added to provide a solid which was collected by filtration.

Provenance & Evidence