反应详情

To a mixture of commercially available 2-chloro-5-hydroxybenzoic acid (4 g, 23.18 mmol) in dry EtOH (90 mL), concentrated sulphuric acid (1 mL, 17.62 mmol) was added. The mixture was stirred under reflux overnight, then solvent evaporated under reduced pressure and the residue dissolved with DCM. A saturated solution of NaHCO3 was added, phases were separated, organics dried over sodium sulphate, filtered and evaporated to obtain 5 g of the corresponding 2-chloro-5-hydroxy-benzoic acid ethyl ester.

1. additionwas added
2. temperatureunder reflux overnight
3. customsolvent evaporated under reduced pressure
4. dissolutionthe residue dissolved with DCM
5. additionA saturated solution of NaHCO3 was added
6. customphases were separated
7. dry with materialorganics dried over sodium sulphate
8. filtrationfiltered
9. customevaporated