Ammonium Acetate → HCID 178493441, compound

Participants

Reaction Conditions

Reaction Steps

To the product from Step B (40 mg, 0.077 mmol) in acetic acid (1 mL) was added ammonium acetate (179 mg, 2.323 mmol) and the mixture heated at 100° C. for 40 h. The solvent was removed and the yellow oil was purified by reverse phase HPLC(YMC Pro-C 18 column, gradient elution, 20% to 90% acetonitrile/water with 0.1% TFA) to afford the title compound as a colorless amorphous solid. LC/MS 498.1 (M+1). IC50 value=B rating

Provenance & Evidence