Hydrochloric Acid → Icotinib hydrochloride

Participants

Reaction Steps

Icotinib (500 mg) was added into 100 mL of reaction flask and dissolved with 40 mL of THF. Hydrogen chloride gas was added while stirring. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (500 mg).

Provenance & Evidence